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Allan D Sherry
Green Distinguished Chr BioSci-Chemistry Department
Office MailstopMail Box: BE26, BE3516, Room No.: BE 3.516 
Email Address  sherry@utdallas.edu    Primary Phone Number 972-883-2907    Media Contact
 Professional Preparation
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 DegreeMajorInstitutionYear
 Ph.D.Inorganic ChemistryKansas State University1971
 B.S.ChemistryWisconsin State University1967
Collapse Section Expand Section Research and Expertise
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Research Description

Our chemistry group at UT-Dallas is involved in the design of novel MR imaging agents that are responsive to physiology and metabolism.

  • High relaxivity Gd3+-based agents that respond to binding events in vivo.

  • Slow water exchange paramagnetic complexes that introduce MR contrast by a novel mechanism called chemical exchange saturation transfer (CEST). Paramagnetic CEST agents are now widely referred to a PARACEST agents.

Collapse Section Expand Section Publications
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  YearPublication  Type
2012
“Europium(III) DOTA-tetraamide Complexes as Redox Active MRI Sensors”, J Ratnakar, S Viswanathan, Z Kovács, K Green, A Jindal & AD Sherry, J Amer Chem Soc, 134, 5798-5800 (2012).
Other
2012
“PET and MR Agents for Molecular Imaging of Cancer Metabolism”, Y Wu, X Sun & AD Sherry, in Principles of Molecular Diagnostics and Personalized Cancer Medicine, edited by Dongfeng Tan, MD, and Henry Lynch, MD, Lippincott, Williams & Wilkins, 2012.
Other
2011
“Flux Through Hepatic Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase Detected by Hyperpolarized 13C Magnetic Resonance”, ME Matthew , Harrison C, AD Sherry, CR Malloy SC Burgess, Proc. Natl. Acad. Sci. USA, 108, 19084-9 (2011).
Other
2011
“Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent”, AJ Lubag, LM De Leon-Rodriguez, SC Burgess, &AD Sherry, Proc. Natl. Acad. Sci. USA, 108, 18400-18405 (2011).
Other
2011
“Imaging the Extracellular pH of Tumors by MRI after Injection of a Single Cocktail of T1 and T2 Contrast Agents”, GV Martinez, X Zhang, ML García-Martín, DL Morse, M Woods, AD Sherry & RJ Gillies, NMR in Biomed., 24, 1380-1391 (2011).
Other
Collapse Section Expand Section Appointments
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DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
2005-PresentAssociate Editor  The journal "Contrast Media for Molecular Imaging", John Wiley
2005-PresentDistinguished ChairSystems Biology The University of Texas at Dallas
2005-PresentDirectorAdvanced Imaging Research Center UT Southwestern Medical Center, Dallas
2002-2005Cecil & Ida Green Honors ChairDepartment of Chemistry The University of Texas at Dallas
1997-1997Scientific Founder  Macrocyclics, Inc.
1991-PresentProfessorRadiology UT Southwestern Medical Center, Dallas
1983-1984NIH Senior Fellow  UT Southwestern Medical Center, Dallas
1982-PresentProfessorDepartment of Chemistry The University of Texas at Dallas
1979-1990HeadPrograms in Chemistry The University of Texas at Dallas
1976-1982Adjunct Associate ProfessorBiochemistry and Biophysics University of Texas Health Science Center at Dallas
1976-1982Associate Professor  The University of Texas at Dallas
1975-1980Visiting Staff Member  Los Alamos Scientific Laboratories
1974-1976Adjunct Assistant ProfessorBiochemistry and Biophysics University of Texas Health Science Center at Dallas
1972-1976Assistant Professor  The University of Texas at Dallas
1971-1972NIH Postdoctoral Fellow  New Mexico State University
 Support
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 DurationTitleSponsorAmountStatus
09/2006-08/2011Metabolic Imaging AgentsNational Institutes of Health (RR grant)$1,025,000Current
09/2006-08/2011Targeted and Responsive MR and PET Agents for B-cell ImagingNational Institutes of Health (PPG)$2,027,590Current
08/2005-07/2010PARACEST for Molecular Imaging of Cancer by MRINational Institutes of Health (ROI)$888,750Previous
06/2005-05/2008Lanthanide-based CEST Agents for Metabolic ImagingRobert A. Welch Foundation$180,000Previous
07/2002-06/2007Intermediary Metabolism in the Heart by NMR SpectroscopyNational Institutes of Health (ROI )$1,125,000Previous
08/2001-06/2006High Relaxivity, Responsive MR Imaging AgentsNational Institutes of Health (RR grant)$354,950Previous
06/2002-05/2005Lanthanide DOTA-tetraamide Complexes as Biological SensorsRobert A. Welch Foundation$150,000Previous
01/2002-12/2004MT Contrast Agents: A New Paradigm in Molecular ImagingState of Texas Advanced Technology Program$150,000Previous
01/2000-12/2004MRI Agents Sensitive to Biological Indicators of NeoplasmNational Institutes of Health (R21/33)$635,314Previous
06/1999-05/2002New Macrocyclic Ligands for Monitoring Extracellular CalciumRobert A. Welch Foundation$126,000Previous
07/1998-06/2002Intermediary Metabolism in the Heart by NMR SpectroscopyNational Institutes of Health (ROI)$1,022,696Previous
09/1998-08/2001New Ligand Systems for Monitoring Biological Cations by NMRNational Institutes of Health (RR grant)$286,112Previous
06/1996-05/1999New Macrocyclic Ligands for Chelating LanthanidesRobert A. Welch Foundation$102,000Previous
03/1997-02/1998Synthesis and Characterization of Polymeric Contrast AgentsBracco Research, USA$53,000Previous
07/1994-06/1998Intermediary Metabolism in the Heart by NMR SpectroscopyNational Institutes of Health (ROI )$1,221,072Previous
09/1993-08/1998New Chelates for Monitoring Intracellular Cations: NMR Spectroscopy of Perfused Tissue and Intact AnimalsNational Institutes of Health (RR grant)$250,000Previous
03/1996-02/1997Synthesis and Characterization of Polymeric Contrast AgentsBracco Research, USA$53,000Previous
06/1993-05/1996Chelates for Measurement of Intracellular IonsRobert A. Welch Foundation$91,000Previous
01/1993-12/1995Development of Liver MRI Contrast AgentsDow Chemical Co.$150,000Previous
06/1993-03/1995Bi- and Trifunctional DO2A MacrocyclesMolecular Biosystems, Inc.$174,764Previous
07/1991-06/1994Intermediary Metabolism in the Heart by NMR SpectroscopyNational Institutes of Health (ROI)$537,187Previous
06/1990-05/1993Chelates for Measurement of Intracellular Ion ConcentrationsRobert A. Welch Foundation$90,000Previous
06/1988-05/1991The Study of Intermediary Metabolism in Whole Cells and Perfused Organs by NMR SpectroscopyThe Meadows Foundation$250,000Previous
07/1988-06/1991Intermediary Metabolism in the Heart by NMR SpectroscopyNational Institutes of Health (ROI)$418,040Previous
06/1989-07/1990Evaluation of Paramagnetic Chelates as MRI Contrast AgentsDallas Biomedical Corporation$87,755Previous
06/1987-05/1990Lanthanide Chelates as Agueous Shih ReagentsRobert A. Welch Foundation$75,000Previous
01/1986-03/1990Development of New Gadolinium MRI Contrast AgentsMallinckrodt, Inc.$336,000Previous
06/1984-05/1987Lanthanide Chelates as Aqueous Shift ReagentsRobert A. Welch Foundation$60,000Previous
07/1983-12/1984Carbon-13 Studies of Con A-Cell Receptor InteractionsNational Institutes of Health (ROI )$32,395Previous
06/1982-05/1984Lanthanide Chelates as Aqueous NMR Shift ReagentsRobert A. Welch Foundation$33,000Previous
04/1980-03/1983Carbon-13 Studies of Con A-eptor InteractionsCell RecNational Institutes of Health (ROI )$199,560Previous
06/1979-05/1982Nuclear Magnetic Resonance Investigations of Lectin-Cell InteractionsRobert A. Welch Foundation$42,000Previous
04/1977-03/1980Lanthanide Ions as Probes of Con A-Cell InteractionsNational Institutes of Health (ROI )$148,235Previous
06/1977-05/1979Nuclear Magnetic Resonance Investigations of Lectin-Cell InteractionsRobert A. Welch Foundation$24,000Previous
05/1974-04/1977Lanthanide Ions as Spectroscopic Probes of Metal Binding Sites in ProteinsRobert A. Welch Foundation$30,000Previous
04/1974-03/1977Lanthanide Ions as Spectroscopic Rulers in Concanavalin ANational Institutes of Health (ROI)$56,813Previous
06/1973-12/1974Lanthanide Complexes as Aqueous NMR Shift ReagentsResearch Corporation$5,000Previous
 News Articles
Magnetic Imaging Researcher’s Work Recognized
UT Dallas News Center

Dr. Dean Sherry, professor of chemistry at UT Dallas, has been elected as a Fellow of the International Society for Magnetic Resonance in Medicine.  Sherry is one of only a handful of scientists chosen by the Society each year to receive the fellowship status.

Sherry began his career at UT Dallas in 1972. His expertise includes developing new types of imaging agents and using imaging to gain insight into human metabolism.

Sherry holds the Cecil H. and Ida Green Distinguished Chair in Systems Biology, and has a joint appointment at UT Southwestern Medical Center as a professor of radiology and director of the Advanced Imaging Research Center.

“It’s exciting to be recognized by my peers,” Sherry said. “I’ve been involved with this organization for several years now, and I was honored by the award.”


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 Additional Information
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AWARDS, FELLOWSHIPS, SOCIETIES & STUDY SECTIONS
  • NSF Research Trainee, 1970-1971, Kansas State University
  • NIH Postdoctoral Fellow, 1971 -1972, New Mexico State University
  • AWU-AEC Summer Faculty Fellowship, 1975, Los Alamos Scientific Lab.
  • NIH Senior Fellow, 1983-1984, University of Texas Health Science Center
  • W.T. Doherty Award, 1990, DFW Section ofthe American Chemical Society
  • UT-Dallas Chancellor's Council Outstanding Teaching Award, 1994
  • American Chemical Society, Phi Kappa Phi, Phi Lambda Upsilon
  • NIH Study Section Member, Biophysical Chemistry (BBCB), 1999-2003
  • Advisor for establishing the NIH Imaging Agent Roadmap database
  • Extemal Advisory Board Member, Molecular Imaging Program, NIH

PATENTS
  1. "Gadolinium Chelates as NMR Contrast Agents", U.S. Patent 4,639,365 Filed: Oct. 18, 1984 lssued: Jan 27, 1987.
  2. "Triazamacrocyclic NMR Contrast Agents and Methods for Their Use", U.S. Patent 4,983,376 Filed: Dec. 28, 1988 Issued: Jan. 8, 1991.
  3. "Zeolite-Enclosed Transition and Rare Earth Metal lons as Contrast Agents for the Gastrointestinal Tract", K. Balkus, A.D. Sherry & S. Young, U.S. Patent 5,122,363 Filed: Dec. 7, 1990 Issued: Jun. 16, 1992.
  4. "Method of Determining Sources of Acetyl-CoA Under Nonsteady-State Conditions", with C.R. Malloy & F.M.H. Jeffrey, U.S. Patent 5,413,917 Filed: July 18, 1990 Issued: May 9, 1995.
  5. "NMR Contrast Agents and Methods For Their Use", U.S. Patent 4,983,376 Filed: Dec. 28, 1988 Issued: January 8, 1991.
  6. "Using Polyazamacrocyclic Compounds for Intracellular Measurement of Metal lons Using MRS", A.D. Sherry, I. Lazar, E. Brucher & R. Ramasamy, U.S. Patent 5,188,816 Filed: November 26, 1991 lssued: February 23, 1993.
  7. "Polyazamacrocycles for Complexation of Metal 1ons", A.D. Sherry, 1. Lazar, E. Brucher & R. Ramasamy, U.S. Patent 5,342,606 Filed: November 19, 1990 Issued: Aug. 30, 1994.
  8. "Synthesis if Polyazarnacrocyles with More Than One Type of Side-Chain Chelating Group (MRI methods)", A.D. Sherry & J. van Westrenen, U.S. Patent 5,316,757 Filed: December 13, 1991 Issued: May 31, 1994.
  9. "Synthesis if Polyazamacrocyles with More Than One Type of Side-Chain Chelating Group (Synthetic method, composition)", A.D. Sherry & J. van Westrenen, U.S. Patent 5,428,155 Filed: May 27, 1994 lssued: June 27, 1995.
  10. "Carboxamide Moditied Polyamine Chelators and Radioactive Complexes Thereof for Conjugation to Antibodies", W.J. Kruper, Jr., W.A. Fordyce & A.D. Sherry, U.S. Patent 5,310,535 Filed: Apr. 24, 1992 Issued: May 10, 1994.
  11. "Alkyl Phosphonate Polyazamacrocyclic Chelates for MR1", A.D. Sherry & G. Kiefer, U.S. Patent 5,362,476 Filed: July 13, 1992; Issued: Nov. 8, 1994.
  12. "Molecular Sieve-Enclosed Transition and Rare Earth Metal Ions as Contrast Agents for the Gastrointestinal Tract", S. Young, K. Balkus, & A.D. Sherry, U.S. Patent 5,429,814 Filed: December 7, 1990. Issued: July 4, 1995.
  13. "13C Isotopomer Analysis in lntact Tissues using {l3C}Homonuclear Decoup1ing", A.D. Sherry, C.R. Malloy, & P Zhao, U.S. Patent 5,597,548. Filed: 7/3/95. Issued: 1/28/97.
  14. "Po1yazamacrocyclic Compounds for Complexation of Metal Ions", A.D. Sherry, 1. Lazar, E. Bnrcher & R. Ramasamy, European Patent Issued, 10/23/96.
  15. "Polyazamacrocyclic Compounds for Complexation of Metal 1ons", A.D. Sherry & G.E. Kiefer, European Patent Issued, 11/21/97.
  16. "Phosphorylated Polyazamacrocyclic Compounds for Complexation of Metal 1ons", A.D. Sherry & G.E. Kiefer, U.S. Patent 5,630,997. Filed: 11/8/94 1ssued: May 20, 1997.
  17. "Molecular Sieve-Enclosed Transition and Rare Earth Metal lons as Contrast Agents for the Gastrointestinal Tract", S. Young, K. Balkus, & A.D. Sherry, Japanese Patent lssued: November 7, 1997.
  18. "Molecular Sieve-Enclosed Transition and Rare Earth Metal Ions as Contrast Agents for the Gastrointestinal Tract", S. Young, K. Balkus, & A.D. Sherry, Singapore Patent 9607688-0 Issued: November 14, 1997.
  19. "Determination of Intracellular Sodium and Potassium Ions by NMR°±, A.D. Sherry, C.R. Malloy & N. Bansal, U.S. Patent 5,951,473. Filed: 5/24/94; Issued: 9/14/99.
  20. "Methods for Determining Gluconeogenesis, Anapleurosis, and Pyruvate Recycling", J. Jones, A.D. Sherry, F.M.H. Jeffrey, G.L. Cottam & C.R. Malloy, U.S. Patent 6,329,208. Filed: July 16, 1998; Issued: December 11, 2001.
  21. "Polyazamacrocyclofluoromonoalkylphosphonic Acids and Their Complexes for use as Contrast Agents", A.D. Sherry & G.E. Kiefer, European Patent Issued, 10/27/98.
  22. "Carboxamide Modified Polyamine Chelators and Radioactive Complexes Thereof for Conjugation to Antibodies", W.J. Kruper, Jr., W.A. Fordyce & A.D. Sherry, U.S. Patent 5,739,322. Filed: Apr. 13, 1995 Issued: April 14, 1998.
  23. "pH Sensitive MRI Contrast Agents", A.D. Sherry, S. Zhang & K. Wu, U.S. Patent 6,746,662. Filed: Feb. 9, 2000; lssued Jun. 8, 2004.
  24. "Paramagnetic Metal ion-based Macrocyclic Magnetization Transfer (MT) Contrast Agents and Method of Use", A.D. Sherry, S. Zhang & K. Wu, U.S. Patent 6,875,419, Filed: Nov. 20, 2001, Issued: April 5, 2005.
  25. "Measurement of Gluconeogenesis and Intermediary Metabolism Using Stable lsotopes", J. Jones, A.D. Sherry, C.R. Malloy, US Patent 7,256,047, lssued: Aug 14, 2007.
  26. "Improved Process for Making a Chelating Agent for Labeling Biomolecules using Preformed Active Esters", Z. Kovacs, DS Mudigonda & AD Sherry, U.S. Patent 6,838,557, Filed: Nov 2002, lssued: Jan 4, 2005.
  27. "Preformed Carboxylated Active Ester for Labeling Biomolecules", Z. Kovacs, DS Mudigonda & AD Sherry, U.S. Patent 6,852,854, Filed Nov 2002, Issued: Feb 8, 2005.
  28. "Process for making a chelating agent for labeling biomolecules using preformed active esters", Z. Kovacs, DS Mudigonda & AD Sherry, U.S. Patent 6,838,557, Filed Nov. 2002, Issued: Jan 4, 2005.
  29. "Lactate Dehydrogenase as a Novel Target and Reagent for Diabetes Therapy", Christopher Newgard, Mette Jensen, A. Dean Sherry & Shawn Burgess, UTSD: 0984. Filed: January 21, 2003.
  30. "Selection of Coordination Geometry to Adjust Water Exchange Rates of Paramagnetic Metal lon-Based Macrocyclic Contrast Agents", AD Sherry, M Woods & Z Kovacs, US Patent Filed: July 2003.
  31. "Bifunctional polyazamacrocyclic chelating agents", Z. Kovaks, Garry E Kiefer, Corinne Bensimon, A. Dean Sherry, Gyula Tirsco, PCT 1nt. Appl, WO 2007104135 (2007).

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