The Professional Preparation section lists academic qualifications such as degrees and diplomas. Each record stores the degree, major, institution and year. The records can also be hidden from public view by checking the hide checkbox. Please click here for available slides.
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Dr. Levene's research interests involve protein-DNA interactions in site-specific recombination and the structure and dynamics of nucleic acids in solution.
Chemical and enzymatic probing methods are powerful techniques for examining details of sequence-dependent structure in DNA and RNA. Reagents that cleave nucleic acid molecules in a structure-specific, but relatively sequence-non-specific manner, such as hydroxyl radical or DNase I, have been used widely to probe helical geometry in nucleic acid structures, nucleic acid-drug complexes, and in nucleoprotein assemblies. Application of cleavage-based techniques to structures present in superhelical DNA has been hindered by the fact that the cleavage pattern attributable to supercoiling-dependent structures is heavily mixed with non-specific cleavage signals that are inevitable products of multiple cleavage events. We present a rigorous mathematical procedure for extracting the cleavage pattern specific to supercoiled DNA and use this method to investigate the hydroxyl radical cleavage pattern in a cruciform DNA structure formed by a 60 bp inverted repeat sequence embedded in a negatively supercoiled plasmid. Our results support the presence of a stem-loop structure in the expected location and suggest that the helical geometry of the cruciform stem differs from that of the normal duplex form.
The Publications section lists any and all publications worked on. Research Explorer's search engine indexes data in this field for keyword searches. The category field is a user defined field where any number of categories can be created by the user to categorize publications. For example, publications can be categorized by the Journal that they appear in. Please click here for available slides.
Metzler, R. , Hanke, A., Zhang, Y., and Levene, S.D. Single DNA conformations and biological function. Computational and Theoretical Nanoscience (in press).
Vetcher, A.A., Srinivasan, S., Vetcher, I.A., Abramov, S.M., Kozlov, M., Baughmann, R.H., and Levene, S.D. Fractionation of SWNT/nucleic acid complexes by agarose gel electrophoresis Nanotechnology 17, 4263-4269 (2006).
Vetcher, A.A., Lushnikov, A.Y., Navarra-Madsen, J., Scharein, R.G., Darcy, I.K., Lyubchenko, Y.L., and Levene, S.D. DNA topology and geometry in Flp and Cre recombination. J. Mol. Biol. 357, 1089-1104 (2006).
Zhang, Y., McEwen, A.E., Crothers, D.M., and Levene, S.D. Statistical-mechanical theory of DNA looping. Biophys. J. 90, 1903-1912 (2006).
You, L. and Levene, S.D. Bulge defects do not destabilize negatively supercoiled DNA. Biophys. J. 89, L43-L45 (2005).
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Ad hoc member, NIH Macromolecular Structure and Function study section (MSFB).
Editorial Board Member, Journal of Experimental Biology and Medicine.
Instructor, Summer Institute Program to Increase Diversity (SIPID), an NHLBI-funded training program for underrepresented minority and disabled junior scientists.
Mentor, Summer Institute of Biomedical Scholars at UT-Dallas (a summer research program for undergraduates and gifted high-school students sponsored by the UT-Dallas Sickle Cell Disease Research Center).
Affiliated faculty member, UT-Dallas graduate program in Bioinformatics and Computational Biology and graduate program in Biotechnology.
Research Fellow, Obermann Center for Advanced Studies, University of Iowa, 2005. Mathematical Sciences Research Institute/Program
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UT Dallas biology professor Stephen D. Levene has been asked to serve on a panel debating the film Expelled: No Intelligence Allowed.
Dr. Levene will speak against the movie’s premise, which accuses academia of unfair bias against educators who espouse the theory of intelligent design.
The Dallas Philosopher’s Forum is hosting the discussion at 7:15 p.m. Tuesday, April 29, at the Angelika Mockingbird Theater. It will include an open question-and-answer session. The event is free for forum members and $5 for non-members.
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