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The central theme of my research is to understand the chemistry and biology of peptides and proteins and to develop new approaches for manipulating these properties with purposefully designed small organic molecules. We employ chemical synthesis and combinatorial chemistry as well as spectroscopic and biophysical methods to accomplish these aims. Projects include:
Development of peptidomimetics for the treatment of Diabetes Mellitus
Development of therapeutic agents for biodefense against bacterial infection
Structure-activity relationship study of glucagons-like peptide-1 and development of its peptidomimetics for the treatment of diabetes mellitus and obesity
Design and synthesis of small organic compounds for detoxification of lipopolysaccharides for potential treatment of sepsis
Development of a new detection method using functionalized carbon nanotube for direct electrical property measurement in pursuit of high-throughput screening systems
The Publications section lists any and all publications worked on. Research Explorer's search engine indexes data in this field for keyword searches. The category field is a user defined field where any number of categories can be created by the user to categorize publications. For example, publications can be categorized by the Journal that they appear in. Please click here for available slides.
"Solid-phase synthesis of tris-benzamides as alpha-helix mimetics." Lee, T.-K., Ahn, J.-M., ACS Comb. Sci. (2011) 13:107-111.
"Development of potent GLP-1 agonists with high enzyme stability by introducing multiple lactam bridges." Murage, E.N., Gao, G., Bisello, A., Ahn, J.-M., J. Med. Chem. (2010) 53:6412-6420.
Eunice Murage, Martin Beinborn, and Jung-Mo Ahn, Seeking for Alpha-Helical Propensity in a Receptor-Bound Conformation of Glucagon-Like Peptide-1. Peptides: Chemistry, Structure and Biology, Proceedings of the 20th American Peptide Symposium. E. Escher, W. D. Lubell, and S. Del Valle, Eds., Springer, New York, NY, pp.289-290 (2009).
Eunice Murage, Jonathan C. Schroeder, Martin Beinborn, and Jung-Mo Ahn, Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1, Bioorg. Med. Chem. 2008, 16, 10106-10112.
Salvatore Di Maro and Jung-Mo Ahn, Development of an Efficient Solid Phase Synthetic Methodology to Construct a Combinatorial Library of a Potent HDAC Inhibitor. Peptides: Chemistry, Structure and Biology, Proceedings of the 20th American Peptide Symposium. E. Escher, W. D. Lubell, and S. Del Valle, Eds., Springer, New York, NY, pp.17-18 (2009).
Presentations and Projects
The Presentations and Projects section lists anything that does not fit in the publication category such as conferences, seminars, invited talks, etc. Research Explorer's search engine indexes data in this field for keyword searches. Please click here for available slides.
Glucagon Amacrine Cells Prevent Deprivation Myopia in Chick K. A. Lencses, J.-M. Ahn, V. J. Hruby, and W. K. Stell, Glucagon Amacrine Cells Prevent Deprivation Myopia in Chick. Society for Neuroscience, New Orleans, November 2000.
Design and Synthesis of Truncated and Conformationally Constricted Glucagon Analogues Jung-Mo Ahn, Matthew Medeiros, Peter M. Gitu, Dev Trivedi, and Victor J. Hruby, Design and Synthesis of Truncated and Conformationally Constricted Glucagon Analogues. 16th American Peptide Symposium, Minneapolis, MN, June, 1999.
Protecting Groups in the Preparation of Cyclic Glucagon Analogues Peter M. Gitu, Paolo Grieco, Jung-Mo Ahn, and Victor J. Hruby, The Use of Allyl (All) and Allyloxycarbonyl (Alloc) Protecting Groups in the Preparation of Cyclic Glucagon Analogues. 16th American Peptide Symposium, Minneapolis, MN, June 1999.
Replacement at Positions 17, 18, and 21 of Glucagon Leads to Formation of a New Salt Bridge and to an Increase in Binding Affinities Dev Trivedi, Jung-Mo Ahn, Ying Lin, John L. Krstenansky, Victor J. Hruby, and Stephen K. Burley, Replacement at Positions 17, 18, and 21 of Glucagon Leads to Formation of a New Salt Bridge and to an Increase in Binding Affinities. 15th American Peptide Symposium, Nashville, TN, June 1997.
Conformational Study of [des-His1, des-Phe6, G lu9]Glucagon Amide by 2D-NMR Spectroscopy in the Presence of Perdeuterated Dodecylphosphocholine Jung-Mo Ahn, Neil E. Jacobsen, Michael F. Brown and Victor J. Hruby, Conformational Study of [des-His1, des-Phe6, G lu9] Glucagon Amide by 2D-NMR Spectroscopy in the Presence of Perdeuterated Dodecylphosphocholine. 17th American Peptide Symposium, San Diego, June 2001.
Small Molecule Could Have Big Impact on Prostate Cancer
Dr. Jung-Mo Ahn, associate professor of chemistry at The University of Texas at Dallas, has designed and synthesized a novel, small molecule that might become a large weapon in the fight against prostate cancer.
In a study published online May 28 in the journal Nature Communications, Ahn and his colleagues at UT Southwestern Medical Center describe the design of the molecule, as well as laboratory tests that show its effectiveness at blocking the cancer-promoting function of proteins called androgen receptors.
Androgen receptors are found inside cells and have complex surfaces with multiple “docking points,” where various proteins can bind to the receptor. Each docking point has a unique shape, so only a correctly shaped molecule will fit.
Researcher Lands Grant from Texas Cancer Initiative
Molecules that attempt to trick cancer cells into killing themselves off are the latest weapons being tested to wage and win the war on cancer. The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded $886,000 to Dr. Jung-Mo Ahn to study a new class of molecules designed to wring the life out of prostate cancer cells. Ahn, an assistant professor of chemistry, is testing compounds called tris-benzamides.
Tris-benzamides may coax cancer cells into behaving like normal cells, which eventually allow themselves to die in a process called apoptosis, or programmed cell death.
“Cancer cells bypass apoptosis by overproducing anti-apoptotic proteins that block the cells from dying, so they live on and wreak havoc in the body,” Ahn said. “Our tris-benzamides are specially designed to lock into the surface of anti-apoptotic proteins. It gives cancer cells a wake-up call that it’s time to die off.”
The Additional Information section describes any other topics you wish to display on your profile that is not in another section. Research Explorer's search engine indexes data in this field for keyword searches. Please click here for available slides.
2007 Junior Faculty Award, American Diabetes Association
2001 Bruce W. Erickson Young Investigator's Award at 17th American Peptide Symposium
1999 Travel Award, American Peptide Society
1997 Hruby Scholar in Peptide Research
1996 Mid-Career fellowship, Department of Chemistry, University of Arizona
1992 Graduated summa cum laude from Department of Chemical Technology, College of Engineering, Seoul National University
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