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Hyuntae Yoo
Assistant Professor
Office MailstopMail Box: FO31, BE, Room No.: 3.204A 
Email Address  hyuntae.yoo@utdallas.edu    Primary Phone Number 972-883-4128    Secondary Phone Number 972-883-2409    Media Contact
 Professional Preparation
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 DegreeMajorInstitutionYear
 Ph.D.Biological ChemistryMassachusetts Institute of Technology2005
 B.S.ChemistrySeoul National University1998
Collapse Section Expand Section Research and Expertise
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2010 - (Present): University of Texas at Dallas
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Research activities in my laboratory are mainly based on high-throughput analysis and functional integration of the results, with the overarching goal of discovery and validation of novel biomarkers and therapeutic targets for human diseases. 

   Lung cancer has been the major target of our research.  Inspired by the 2009 discovery of 2-hydroxyglutarate as cancer-specific diagnostic marker for glioma, we used a unique combination of approaches based on mass spectrometry and systems biology on lung cancer to discover a novel blood biomarker for early detection of lung cancer (N-acetylaspartate: NAA) and two genes as novel therapeutic targets for lung cancer treatment. 

  In particular, the discovery and validation of NAA was made in close collaboration with the University of Texas Southwestern Medical Center (UTSWMC). We are currently working closely with collaborators at UTSWMC and University of Toledo to further evaluate the potential of NAA blood test in clinical settings and to investigate mechanistic basis of NAA production.

 One of the two novel genes with therapeutic potentials plays an important role in selective transport of a unique set of amino acids. We are currently validating these findings and preparing to submit the manuscript for a peer-reviewed publication.

2008- 2010: Institute for Systems Biology

Research Scientist (Research advisor: Dr. Leroy Hood)

  1. Biomarker Discovery for Prion Disease – in collaboration with Dr. George Carlson
    • Discovered serum biomarker candidates for early diagnosis of prion disease with development of novel quantitative proteomic approaches in mouse
  2. Biomarker Discovery for Vx-induced Neurotoxicity – in collaboration with Dr. Jennifer Sekowski
    • Developing serum biomarker candidates for early diagnosis of Vx-induced neurotoxicity through multiple reaction monitoring-based targeted proteomics on blood samples from rat models
  3. Biomarker Discovery for Traumatic Brain Injury – in collaboration with Dr. Howard Federoff
    • Developing serum biomarker candidates for early diagnosis of Traumatic Brain Injury through multiple reaction monitoring-based targeted proteomics on blood
  4. samples of human subjects
  5. Biomarker Discovery for Post-Traumatic Stress Disorder (PTSD) – in collaboration with Drs. Charles Marmar and Marti Jett
    • Developing serum biomarker candidates for early diagnosis of PTSD through multiple reaction monitoring-based targeted proteomics on blood samples from mouse models and human subjects
2005 - 2008 Institute for Systems Biology

Postdoctoral Fellow (Research advisor: Dr. Leroy Hood)

  1. Systems Approach to Prion Disease – in collaboration with Dr. George Carlson
    • Applied systems approach to molecular understanding of prion disease with mouse brain transcriptomics and network analysis
  2. Biomarker Discovery for Liver toxicity
    • Discovered serum biomarker candidates for early diagnosis of drug
2001 - 2005 Massachusetts Institute of Technology
  1. Research Assistant (Research advisor: Professor Gregory Stephanopoulos)
  2. Metabolic analysis of lipid biosynthesis in mouse adipose cells
    • Quantified carbon sources for triglycerides in cultured brown adipose cells with GC-MS
    • Discovered novel biological reaction in the pathway from glutamine to fatty acid synthesis with stable-isotope labeling, GC-MS analysis, and novel metabolic flux analysis
1998 - 1999 Seoul National University

Postundergraduate Research Assistant (Research advisor: Professor B. Moon Kim)

  • Developed one-step synthesis of a key linker molecule for synthesis of improved HIV protease inhibitor
Collapse Section Expand Section Publications
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 1  2 3  
  YearPublication  Type
2016

Lou TF, Sethuraman D, Dospoy P, Srivastva P, Kim HS, Kim J, Ma X, Chen PH,
Huffman KE, Frink RE, Larsen JE, Lewis CM, Um SW, Kim DH, Ahn JM, DeBerardinis
RJ, White M, Minna JD, Yoo H.
 
Cancer-specific production of N-acetylaspartate via
NAT8L overexpression in non-small cell lung cancer and its potential as a
circulating biomarker. 
 
Cancer Prev Res (Phila). 2016 Jan;9(1):43-52.
 

Category: Cancer Metabolism
Peer reviewed
2016

Hyuntae Yoo, Inyoul Lee, Daehee Hwang, David Baxter, Rose Pitstick, George A. Carlson, Leroy E. Hood

Presymptomatic diagnosis of prion disease with brain specific secreted proteins in mouse blood plasma.

(Manuscript in preparation)


Category: Systems Biology
Other
2014

Z. Hu, C. Lausted, H. Yoo, X. Yan, A. Brightman, J. Chen, W. Wang, X. Bu, L. Hood,

Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity.

Theranostics 4 (2014) 215-228.

http://www.thno.org/v04p0215.htm


Category: Systems Biology
Peer reviewed
2009

Daehee Hwang*, Inyoul Y. Lee*, Hyuntae Yoo*, Nils Gehlenborg, Ji-Hoon Cho, Brianne Petritis, David Baxter, Rose Pitstick, Rebecca Young, Doug Spicer, John Hohmann, Stephen J. DeArmond, George A. Carlson, Leroy E. Hood

A Systems Approach to Prion Disease.

Molecular Systems Biology (2009) 5:252.

(* denotes equal contribution.)

http://msb.embopress.org/content/5/1/252.long


Category: Systems Biology
Peer reviewed
2009

Nils Gehlenborg*, Daehee Hwang*, Inyoul Y. Lee*, Hyuntae Yoo, David Baxter, Brianne Petritis, Rose Pitstick, Bruz Marzolf, Stephen J. DeArmond, George A. Carlson, Leroy Hood (2009) The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database (0):bap011.


Category: Database
Peer reviewed
Collapse Section Expand Section Presentations and Projects
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  1  
Start DateEnd DatePresentation/Project
09/01/2010 12/31/2015 [To Be Updated]

[To Be Updated]

  [To Be Updated]
Collapse Section Expand Section Appointments
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DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
2012-PresentAdjunct ProfessorBiomedical Engineering Univ. of Texas Southwestern Medical Center
2010-PresentAssistant ProfessorBiology/Bioengineering deptsNatural Sciences & Mathematics / ECSUniversity of Texas at Dallas
2008-2010Research ScientistHood group Institute for Systems Biology
2005-2008Postdoctoral FellowHood group Institute for Systems Biology
2001-2005Research AssistantStephanopoulos group Massachusetts Institute of Technology
1999-2000Teaching AssistantChemistry Massachusetts Institute of Technology
1998-1999Postundergraduate Research AssistantB. Moon Kim group Seoul National University
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 Additional Information
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Reviewer for Scientific Journals

Ad-hoc reviewer for Cancer Prevention Research, PLOS ONE, Proceedings of the National Academy of Sciences, U.S.A., Journal of Proteome Research, BMC Systems Biology, and American Association for the Advancement of Science


Honors and Activities

2015 – Member of International Association for the Study of Lung Cancer (IASLC)

2012 – Active Member of American Association for Cancer Research (AACR)
2005 – Member of American Society for Mass Spectrometry
2002 Merck Poster Award, Metabolic Engineering IV Conference, Il Ccioco, Italy
1998 Summa Cum Laude, Department of Chemistry, Seoul National University, Korea
1997 Army Commendation Medal, UNCSB, Korea
1992 – 1994 Woojeong scholarship (3 years, full tuition), Seoul National University, Korea


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