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    Faculty Profile — Is this you? Login to edit.Last Modified Time: 04:32:36 PM Wed, 23 Mar 2011 
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Hyuntae Yoo
Research Scientist-Biology/Bioengineering Departments
Office MailstopMail Box: FO31, BE, Room No.: 3.204A 
Email Address  hyuntae.yoo@utdallas.edu    Primary Phone Number 972-883-4128    Secondary Phone Number 972-883-2409    Media Contact
 Professional Preparation
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 DegreeMajorInstitutionYear
 Ph.D.Biological ChemistryMassachusetts Institute of Technology2005
 B.S.ChemistrySeoul National University1998
Collapse Section Expand Section Research and Expertise
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2010 - (Present): University of Texas at Dallas

Functional integration of multi-level systems biology approaches to experimental models of human disease for discovery of novel drug targets

2008- 2010: Institute for Systems Biology

Research Scientist (Research advisor: Dr. Leroy Hood)

  1. Biomarker Discovery for Prion Disease – in collaboration with Dr. George Carlson
    • Discovered serum biomarker candidates for early diagnosis of prion disease with development of novel quantitative proteomic approaches in mouse
  2. Biomarker Discovery for Vx-induced Neurotoxicity – in collaboration with Dr. Jennifer Sekowski
    • Developing serum biomarker candidates for early diagnosis of Vx-induced neurotoxicity through multiple reaction monitoring-based targeted proteomics on blood samples from rat models
  3. Biomarker Discovery for Traumatic Brain Injury – in collaboration with Dr. Howard Federoff
    • Developing serum biomarker candidates for early diagnosis of Traumatic Brain Injury through multiple reaction monitoring-based targeted proteomics on blood
  4. samples of human subjects
  5. Biomarker Discovery for Post-Traumatic Stress Disorder (PTSD) – in collaboration with Drs. Charles Marmar and Marti Jett
    • Developing serum biomarker candidates for early diagnosis of PTSD through multiple reaction monitoring-based targeted proteomics on blood samples from mouse models and human subjects
2005 - 2008 Institute for Systems Biology

Postdoctoral Fellow (Research advisor: Dr. Leroy Hood)

  1. Systems Approach to Prion Disease – in collaboration with Dr. George Carlson
    • Applied systems approach to molecular understanding of prion disease with mouse brain transcriptomics and network analysis
  2. Biomarker Discovery for Liver toxicity
    • Discovered serum biomarker candidates for early diagnosis of drug
2001 - 2005 Massachusetts Institute of Technology
  1. Research Assistant (Research advisor: Professor Gregory Stephanopoulos)
  2. Metabolic analysis of lipid biosynthesis in mouse adipose cells
    • Quantified carbon sources for triglycerides in cultured brown adipose cells with GC-MS
    • Discovered novel biological reaction in the pathway from glutamine to fatty acid synthesis with stable-isotope labeling, GC-MS analysis, and novel metabolic flux analysis
1998 - 1999 Seoul National University

Postundergraduate Research Assistant (Research advisor: Professor B. Moon Kim)

  • Developed one-step synthesis of a key linker molecule for synthesis of improved HIV protease inhibitor
Collapse Section Expand Section Publications
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 1  2 3  
  YearPublication  Type
2011
Hyuntae Yoo, Inyoul Lee, Daehee Hwang, David Baxter, Rose Pitstick, George A. Carlson, Leroy E. Hood (2011) Presymptomatic diagnosis of prion disease with brain specific secreted proteins in mouse blood plasma.
Category: Manuscripts in preparation
Other
2011
Hyuntae Yoo, Zhiyuan Hu, Xiaowei Yan, David Baxter, Amy Brightman, Biaoyang Lin, Leroy Hood (2011) Validation of serum biomarker candidates for liver toxicity with targeted quantitative analysis of serum proteins.
Category: Manuscripts in preparation
Other
2011
Maciek R. Antoniewicz, Hyuntae Yoo, Joanne K. Kelleher and Gregory Stephanopoulos (2010) Global flux quantification and statistical analysis in stable-isotope studies quantifies
effects of IRS-1 knockout in brown adipose cells.

Category: Manuscripts in preparation
Other
2009
Daehee Hwang*, Inyoul Y. Lee*, Hyuntae Yoo*, Nils Gehlenborg, Ji-Hoon Cho, Brianne Petritis, David Baxter, Rose Pitstick, Rebecca Young, Doug Spicer, John Hohmann, Stephen J. DeArmond, George A. Carlson, Leroy E. Hood (2009) A Systems Approach to Prion Disease. Molecular Systems Biology 5:252.
Category: Molecular Systems Biology
Peer reviewed
2009
Nils Gehlenborg*, Daehee Hwang*, Inyoul Y. Lee*, Hyuntae Yoo, David Baxter, Brianne Petritis, Rose Pitstick, Bruz Marzolf, Stephen J. DeArmond, George A. Carlson, Leroy Hood (2009) The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database (0):bap011.
Category: Database
Peer reviewed
Collapse Section Expand Section Presentations and Projects
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  1  
Start DateEnd DatePresentation/Project
October, 2002  Quantification of the Roles of Hormones and Metabolites in Brown Adipocyte Differentiation

Poster (October, 2002): “Quantification of the Roles of Hormones and Metabolites in Brown Adipocyte Differentiation”, Metabolic Engineering IV Conference, Il Ccioco, Italy

March, 2007  Targeted proteomics approach for validation of diagnostic biomarker candidates of prion diseases

Poster (March, 2007): “Targeted proteomics approach for validation of diagnostic biomarker candidates of prion diseases”, US HUPO, Seattle, WA

July, 2008  Introduction to Systems Biology

Invited Lecture (July, 2008): “Introduction to Systems Biology”, McLaughlin Research Institute, Great Falls, MT

February, 2009  Integrative approach for discovery of diagnostic serum biomarkers of prion disease in mice

Invited Conference Presentation (February, 2009): “Integrative approach for discovery of diagnostic serum biomarkers of prion disease in mice”, US HUPO, San Diego, CA

August, 2007  Quantitative Analysis of Carbon Fluxes for Fat Biosynthesis in Wild-type and IRS-1 Knockout Brown Adipocytes

Invited Lecture (August, 2007): “Quantitative Analysis of Carbon Fluxes for Fat Biosynthesis in Wild-type and IRS-1 Knockout Brown Adipocytes”, Sungkyunkwan university, Seoul, Korea

Collapse Section Expand Section Appointments
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DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
2010-PresentAssistant ProfessorBiology/Bioengineering deptsNatural Sciences & Mathematics / ECSUniversity of Texas at Dallas
2008-2010Research ScientistHood group Institute for Systems Biology
2005-2008Postdoctoral FellowHood group Institute for Systems Biology
2001-2005Research AssistantStephanopoulos group Massachusetts Institute of Technology
1999-2000Teaching AssistantChemistry Massachusetts Institute of Technology
1998-1999Postundergraduate Research AssistantB. Moon Kim group Seoul National University
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 Additional Information
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Grant Writing Experience
  1. Wrote proposal to Cancer Prevention & Research Institute of Texas as Principal Investigator (“Recruitment of First Time Tenure-Track Faculty Members”)
    1.     Submitted in August, 2010
    2.     Review pending
  2. Assisted writing NIH P01 proposal on “Systems Analysis of CNS Stem Cells as a model for Early-Stage Progression of Prion Disease” (2006)
    1.     PI: Leroy Hood, M.D., Ph.D.
    2.     Multi-institutional grant
    3.     Drafted large portion of P01 proposal and helped design specific aims
    4.     Proposal approved with NIH funding score of 125
  3. Assisted writing DoD proposal on “Discovery and Validation of Peripheral Biomarkers of Traumatic Brain Injury” (#08023001) (2008)
    1.     PI: Leroy Hood, M.D., Ph.D.
    2.     Multi-institutional grant
    3.     Drafted a portion about development of novel mass spectrometry methods for targeted quantification of protein biomarker candidates in human serum samples
    4.     Proposal approved
  4. Assisted writing DoD proposal on “Blood biomarkers for assessing the exposure and responses of mammals to chemical and biological agents” (#BAA ECBC-04)(2009)
    1.     PI: Leroy Hood, M.D., Ph.D.
    2.     Drafted a portion about discovery of serum biomarkers for nerve agent exposure
    3.     Proposal approved
  5. Assisted writing DoD proposal on “A Systems Approach to Understanding Post-Traumatic Stress Disorder” (2009)
    1.     PI: Leroy Hood, M.D., Ph.D./ David Galas, Ph.D.
    2.     Multi-institutional grant
    3.     Drafted a portion about development of mass spectrometry methods for discovery of novel brain-specific serum biomarkers in presymptomatic diagnosis of Post-Traumatic Stress Disorder in mouse models and human patients
    4.     Proposal approved

Reviewer for Scientific Journals

Ad-hoc reviewer for Journal of Proteome Research and BMC Systems Biology


Honors and Activities

2009 – Member of American Academy of Neurology
2005 – Member of American Society for Mass Spectrometry
2002 Merck Poster Award, Metabolic Engineering IV Conference, Il Ccioco, Italy
1998 Summa Cum Laude, Department of Chemistry, Seoul National University, Korea
1997 Army Commendation Medal, UNCSB, Korea
1992 – 1994 Woojeong scholarship (3 years, full tuition), Seoul National University, Korea


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