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    Faculty Profile — Is this you? Login to edit.Last Modified Time: 02:48:40 PM Tue, 5 Oct 2010 
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John Hart, Jr.
Professor-Behavioral & Brain Science
Office MailstopMail Box: CBH, Center for BrainHealth, Room No.: BH 3.112 
Email Address  jxh057100@utdallas.edu    Primary Phone Number 214-905-3007    URL John Hart's Webpage   URL John Hart's BrainHealth Page    Media Contact
 Professional Preparation
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 DegreeMajorInstitutionYear
 M.D. University of Maryland School of Medicine1983
 B.A.PsychologyThe Johns Hopkins University1979
Collapse Section Expand Section Research and Expertise
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Research Interests

My research interests have focused on the neural basis of semantic memory in the human brain. My work, spanning several decades, has focused on identifying the organization of semantic memory in the human brain by proposing that there is both a categorical and featural structure to object memory that exists in multiple memory systems in the brain. My laboratory's recent studies have used functional neuroimaging and electrophysiological investigations to explore the neural mechanisms underlying combining these components of an object together to form an integrated object memory. They recently reported that one neural mechanism by which object recall can occur is via synchronizing gamma brain rhythms that are modulated by the thalamus and proposed the Neural Hybrid Model of Semantic Memory. I am now investigating object memory and word finding deficits in multiple disease states in terms of both diagnosing and designing treatment options based on this model.

Collapse Section Expand Section Publications
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 2 3 4 Next>> 18>>  
  YearPublication  Type
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Calley, C., Tillman, G., Womack, K., Moore, P., Hart, J., Jr., Kraut, M. Subjective Report of Word-Finding and Memory Deficits in Normal Aging and Dementia. Cognitive and Behavioral Neurology, in press
Peer reviewed
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Tillman, G., Kimbrell, T., Calley, C., Li, J., Kraut, M., Freeman, T., Hart, J., Jr. Selective Reduction of Combat Threat Memory P300 Response after Right Frontal Lobe rTMS in PTSD. The Journal of Neuropsychiatry and Clinical Neurosciences , in press
Peer reviewed
?
Anand, R., Chapman, S., Rackley, A., Keebler, M., Zientz, J., Hart, J. Gist Reasoning Training in Cognitively Normal Seniors. International Journal of Geriatric Psychiatry, in press.
Peer reviewed
?
Xu, F., Uh, J., Brier, M., Hart, J., Yezhuvath, U., Gu, H., Yang, Y., Lu, H. The influence of carbon dioxide on brain activity and metabolism in conscious humans. The Journal of Cerebral Blood flow and Metabolism, in press.
Peer reviewed
?
Calley, C.S., Buhl, V., Tillman, G.D., Green, T.A., Hart, J. Jr., Haley, R.W., Kraut, M.A. Impaired word finding in ill Gulf War veterans. Brain Imaging and Behavior, in press.
Peer reviewed
Collapse Section Expand Section Presentations and Projects
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  1  2 3 4 
Start DateEnd DatePresentation/Project
2004 2004 Neural hybrid model of semantic object recall.
Hart, J International Neuropsychological Association and Australian Society for the Study of Brain Impairment, Brisbane, Australia, 2004. (Brain Impairment 2004; 5: 27).
2004 2004 Delayed matching-to-sample performance across the lifespan: Effects on accuracy and latency.
Gardner, E., Chelonis, J, Dornhojfer, J, Henderson, V, Hart, J, Blake, D., Paule, M Association for Behavior Anabzsis, Boston, 2004.
2004 2004 Absence of anterior cingulate activation in schizophrenic individuals during a semantic feature-binding task.
Rivkin, P., Yassa, M, Hart, J, Kraut, M, Kanaan, R., Calhoun, V, & Pearlson, G. Society of Biological Psychiatry, 2004.
2004 2004 fMRl evidence for abnormal semantic processing in schizophrenia.
Assaf M, Kuzu, C., Rivkin, P, Calhoun, Ii, Kraut, M, Yassa, M, Hart, J, & Pearlson, G. Society of Biological Psychiatry, 2004.
2003 2003 Thalamocortical evidence for a constructive memory framework.
Slotnick, S. & Hart, J Society for Neuroscience, 2003.
Collapse Section Expand Section Affiliations
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Fellows Trained
1999-2001 Lauren Moo, M.D.
1999-2001 Scott Slotnick, Ph.D.
2004-2005 Juan Li, Ph.D.
2006 Richard King, M.D., Ph.D.
2006- Jacque Gamino, Ph.D.
2007-Gail Tillman, Ph.D.
2008-Raksha Anand, Ph.D.
2008-Elizabeth Kanter Bartz, Ph.D.

Graduate student supervisors
2006-2008 Raksha Anand
2006-2007 Peter Fauver
2007-2009 Khamid Bhadikirov
2009-2010 Leonardo Estevez
2009- H-S Chiang
2010- Jeremy Strain
2010- Neena Rao
Undergraduate degree students supervised
1999-2000 Felix Yu
1997-99 Tifiini Smith
1996 Lauren Roginski
2006-10 Matthew Brier
2009-10 Shehznan Baqui
2009-10 Nistha Jajal
2009-10 Michael Lugo
2008-10 Rajen Patel
Medical students supervised
1997-99 W. Leo Sugrue
Residents supervised for senior research tutorial
1996-97 Ellen Deibert, M.D.
1998-99 Lauren Moo, M.D., Isaac Silverman, M.D.
Collapse Section Expand Section Appointments
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DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
2006-PresentDirectorBerman Laboratory in Learning and Memory University of Texas at Dallas
2005-PresentProfessor/ Jane and Bud Smith Distinguished Chair/Cecil Green Chair in Systems BiologyBehavioral and Brain Sciences University of Texas at Dallas
2005-PresentProfessorDepartments of Neurology and Psychiatry University of Texas Southwestern Medical Center
2005-Present Institute of Biomedical Sciences and Technology University of Texas at Dallas
2005-PresentMedical Science DirectorCenter for BrainHealth University of Texas at Dallas
2004-2005Associate DirectorClinical Programs and Evaluation GRECC of CAVHS
2003-2005Associate ProfessorDepartment of Audiology and Speech Pathology University of Arkansas for Medical Sciences
2002-2005Staff PhysicianGeriatrics Central Arkansas Veterans Healthcare System
2002-2005Physician Researcher  GRECC, CAVHS
2002-2005Director  Geriatric Memory Disorders Clinic, CAVHS
2001-2005Associate ProfessorDepts. of Geriatrics, Neurology, and Radiology University of Arkansas for Medical Sciences
2001-2005DirectorLaboratory of Cognition & Brain Imaging Donald W. Reynolds Center on Aging, UAMS
1998-2001Deputy DirectorDivision of Cognitive Neurology and NeuropsychologyDepartment of NeurologyThe Johns Hopkins University
1998-2001ChairmanProtocol Review CommitteeF. M. Kirby Research Center for Functional Brain ImagingKennedy Krieger Institute
1997-2001Neurology Staff  The Johns Hopkins Hospital
1996-2001Assistant ProfessorDepartment of Cognitive Science The Johns Hopkins University
1995-1996Assistant Resident and Resident in Neurology  The Johns Hopkins Hospital
1993-2001Assistant ProfessorDepartment of Neurology The Johns Hopkins University School of Medicine
1990-2001Associate MemberThe Zanvyl Krieger Mind/Brain Institute The Johns Hopkins University
1990-1993Research AssociateDept. of Neurology The Johns Hopkins University School of Medicine
1986-1990Fellow in Cognitive Neurology and NeuropsychologyDept. of Neurology The Johns Hopkins Hospital.
1984-1986Assistant Resident in Neurology  The Johns Hopkins Hospital.
1983-1984Medical lnternship  Union Memorial Hospital, Baltimore, MD.
       Teaching HelpHelp  
 Additional Information
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Certification
  • Behavioral Neurology and Neuropsychiatry, UCNS, 10/23/06

Society Membership
  • Academy of Aphasia (1990-)
  • American Academy of Neurology (1987-)
  • American Assoc. for the Advancement of Science (1987-)
  • American Epilepsy Society (1991-)
  • Behavioral Neurology Society (1987-)
  • Baltimore-Washington Area Neuropsychology Group (1991-)
  • lntemational Neural Network Society (1992-)
  • New York Academy of Sciences (1993-)
  • Society for Neuroscience (1994-)
  • Cognitive Neuroscience Society (2001-)
  • Arkansas Medical Society (2004-)

Honors
  • 1979 Psychology Departmental Honors, The Johns Hopkins University
  • 1982 Dean's Fellowship for Research, University of Maryland School of Medicine
  • 1983 The William Alexander Harmnond Award for Excellence in Neurology, University of Maryland School of Medicine

Doctoral Committees
  • 1996    "Development of nuclear magnetic resonance techniques for functional neuroimaging in human stroke," Brian J. Soher, Ph.D., Department of Biomedical Engineering, The Johns Hopkins University.
  • 1996    "The influence of semantic representations on arithmetic fact," John Whalen, Ph.D., Department of Cognitive Science, The Johns Hopkins University.
  • 2006   “The Effects of the Female Menstrual Cycle on Hemispheric Asymmetry in Dichotic Listening,” Gail Tillman, Ph.D., School of Behavioral and Brain Sciences, The University of Texas at Dallas.
  • 2008    “Differences between GIST and Detail Processing,” Raksha Anand, Ph.D., School of Behavioral and Brain Sciences, The University of Texas at Dallas
  • 2008     “Semantic Priming Effects Across the Lifespan:  an ERP Study,” Jyutika Mehta, Ph.D., School of Behavioral and Brain Sciences, The University of Texas at Dallas.
  • 2008    “Dimensions of Discourse: Diagnostic, Neuroimaging, and Neuropsychological Correlates In Early Fronto-temporal Lobar Degeneration,” Stephanie Chiu Wong, Ph.D., School of Behavioral and Brain Sciences, The University of Texas at Dallas.
  • 2009    “Effects of Middle Age on Interaural Asymmetry in a Competing Speech Task,” Tara Davis, School of     Behavioral and Brain Sciences, The University of Texas at Dallas.

Committees
  • 2006- Protocol Review and Monitoring Committee, Advanced Imaging Research Center, University of Texas
  • 1997-2001 Functional Imaging Committee (The Johns Hopkins University)
  • 1998 Coding and Reimbursement Subcommittee ofthe Scope of Practice Committee (American Academy of Neurology)
  • 1998-2001 Cingulotomy/Psychosurgeiy Review Committee (The Johns Hopkins Hospital)
  • 1998-2001 Committee on Appointments and Promotions (Neurology Department, The Johns Hopkins University School of Medicine)
  • 1999-2001 Chairman, Practice Issues Committee, Behavioral Neurology Section, American Academy of Neurology
  • 1999-2001 Co-Chair, Residency Selection Committee (Neurology Department, The Johns Hopkins University School of Medicine)
  • 2000-2002 Secretary/Treasurer Behavioral Neurology Section of the American Academy of Neurology
  • 2000-2002 Secretary/Treasurer Society for Behavioral and Cognitive Neuroscience
  • 2001 -2004 Chairman, Subspeciality Certification Committee, Behavioral Neurology Section, American Academy of Neurology
  • 2002-2005 President-elect Behavioral Neurology Section of the American Academy of Neurology
  • 2002-2005 President-elect Society for Behavioral and Cognitive Neuroscience
  • 2002 Co-Chairman, Faculty Retreat, Dept. of Geriatrics, UAMS
  • 2002-2005 Co-Chairman, Linkages Committee, Dept. of Geriatrics, UAMS
  • 2004-2005 Adult Day Healthcare Advisory Program Committee, CAVHS
  • 2004-2005 Telehome Care lmplementation Team, CAVHS
  • 2004-2005 V1SN 16, Care Coordination and Telehealth
  • 2005 AAN representative and original sponsor of Functional Brain Mapping billing code approved by AMA CPT Committee
  • 2006 AAN Representative to the RUC for approval and establishment of relative value units to for Functional Brain Mapping (2/2-5/06)
  • 1999- Executive Committee, Behavioral Neurology Section, American Academy of Neurology
  • 2000- Medical Economics and Management Committee, American Academy of Neurology, Behavioral Neurology Representative
  • 2002- Membership Committee, Academy of Aphasia
  • 2005- President Behavioral Neurology Section of the American Academy of Neurology
  • 2005- President Society for Behavioral and Cognitive Neuroscience

Editorial Activities
  • 1998-                Editorial Board, Neurocase
  • 2006-2009       Editorial Board, Neuropsychology
  • 2007-                Editorial Board, Journal of Innovative Optical Health Sciences
  • 2009-                Editorial Board, World Journal of Radiology
  • 2010-                Review Editorial Board, Frontiers in Neuropsychiatric Imaging and Stimulation

AD HOC REVIEWER
  • Journals: Annals of Neurology; Archives of Physical Medicine and Rehabilitation; Behavioral Neurology;Brain; Brain and Language; C ognit1veNeuropsychology; Epilepsia; Journal of Cognitive Neuroscience; Journal of Neurophysiology; Journal of thelnternational Neuropsychological Society; Journal of Theoretical Biology; Lancet; Neuroimage; Neuropsychiatry, Neuropsychology, and Behavioral Neurology; Neurology; Neuropsychologia; Neuroscience Letters, Science
  • Agencies: N1H - Neurology A Study Section (1993-1995); Initial Review Board of the Medical and Scientific Advisory Council of the Alzheimer's Disease and Related Disorders Association (2000-)

Consultant
  • Publications: Time-Life Books
  • Media: CSI- New York

Speaker
Eisai Pharmaceuticals, Pfizer Pharmaceuticals; Bayer Pharmaceuticals

SPEAKER'S BUREAU
  • Forrest Pharmaceuticals

Grant Participation

CURRENT:

  • Principal Investigator, Novel Treatment of Emotional Dysfunction, DOD, CDMRP, W81XWH-09-DMRDP-ARATDA, (year 1 direct costs $750,000, total direct costs $3,000,000, 9/10-8/13).  25% effort.
  • Protocol Co-Chair, HSE Sub-Study: Correlations of Herpes Simplex Virus (HSV) Viral Load with Neuropsychological Outcomes.  NIAID and NINDS (N01-A1-65306, 9/98-8/08; $43,600 yearly direct; $221,419 recent 5 year total direct).   5% effort.
  • Laboratory Director, Berman Laboratory in Learning and Memory, Center for BrainHealth, University of Texas at Dallas, $700,000).  0% effort.
  • Principal Investigator, Human Performance Measures in Humans, Department of Defense (direct costs of project $582,520).  0% effort.
  • Co-PI, Brain and Cognitive Changes after Reasoning or Physical Training in Cognitively Normal Seniors, NIH (year 1 direct costs $379,038, total direct costs $1,000,00, 9/09-8/11).  3% effort.
  • Investigator, Modulation of Brain Activity by Control of the Inspired Air, NIH/NINDS R01 (PI, Lu; Hart PI of UTD subcontract, year 1 UTD direct costs $42,223, total UTD direct costs $225,051, 8/10-7/14).  10% effort.

FORMER:

  • Principal Investigator, Word Retrieval in Gulf War Illness, Veterans Administration (year 1 direct costs $193,180, total costs $285,740; two year project direct costs $381,175, total costs $566,901). 
  • Principal Investigator, Neuropsychiatric Projects, Investigations into Gulf War Illness, Veterans Administration (year 1 direct costs $1,112,318, total costs $2,845,766; two year project direct costs $2,567,897, total costs $3,917,531).
  • Principal Investigator, Neuropsychological and Cognitive Paradigm Sub-Core, Investigations into Gulf War Illness, Veterans Administration (year 1 direct costs $358,101, total costs $508,660; two year project direct costs $718,934, total costs $1,115,593).
  • Principal Investigator, EEG Sub-Core, Investigations into Gulf War Illness, Veterans Administration (year 1 direct costs $608,228, total costs $826, 674; two year project direct costs $954,251, total costs $1,376,257).
  • Co-PI, Emotional Memory Circuits in Gulf War Illness, Veterans Administration (year 1 direct costs $229,547, total costs $354,802; two year project direct costs $442,780; total costs $677,900).
  • Co-PI, Complex Verbal Functions and Basal Ganglia, Veterans Administration (year 1 direct costs $508,407, total costs $773,664; two year project direct costs $987,220, total costs $1,491,168).
  • Protocol Co-Chair, CASG #211 “Investigation of the Natural History of West Nile Virus Infection in Patients with or at Risk for Progression to West Nile Virus Encephalitis and/or Myelitis.”  NIAID and NINDS (N01-A1-65306, 9/98-8/08).
  • Protocol Co-Chair, CASG #210 “A Phase II Randomized Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (Omr-IgG-Am™) Containing High Anti-West Nile Virus Antibody Titers in Patients with, or at Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis.” NIAID and NINDS (N01-A1-65306, 9/98-8/08).  
  • Co-PI, (PI, Nestler), Center for Advanced ADHD Research, Treatment, and Education, Sparrow Foundation (7/06-6/09).
  • Consultant, (PI, Pearlson), Quantitative Neuroimaging in Psychosis (NIMH, MH43775-14, 3/1/05-2/28/09).
  • Co-PI, (PI, Tao), The Role of Prefrontal Cortex and Amygdala in Self-harming Behavior among Depressed Youth, Grants for Collaborative Research UTSW-UTD (5/07-4/08).
  • Investigator, (PI, Sullivan), Manifestations, causes, and consequences of Protein Energy Undernutrition in elderly TCU residents, Investigator Initiated Research Veterans Administration, (6/05-5/07)
  • Collaborator, (PI, Assaf), Differential Diagnosis of Psychotic Patients Investigates Activation Patterns Related to Semantic Retrieval in Manic Bipolar and Schizophrenia Patients, and its Relationship to Formal Thought Disorder Severity (Donaghue Foundation,  7/1/05-6/30/08).
  • Principal Investigator, Monitoring Electrophysiological Changes in Object Recall in Semantic Memory during Feature Binding.  GlaxoSmithKline, (10/02-9/06).
  • Principal Investigator, Predicting Response to Acetylcholinesterase Inhibitors for New Learning and Semantic Memory in Mild Cognitive Impairment and Alzheimer’s Disease, MIRECC, 5/04-4/06).  
  • Principal Investigator, Assessment of Object Memory in Normal Aging and Mild Cognitive Decline. Biomedical Research Fund, VA. (6/02-5/05).
  • Investigator (PI of Core, Liem), Alzheimer’s Disease Center, Clinical Core, NIH, (AG-00-002, 8/02-7/05).
  • Investigator (PI, Chernoff), Geriatric Mental Health on the Move, Arkansas Geriatric Education Center, HRSA, GEC Grant 1D 31 HP80009.      
  • Investigator (PI, Crone), Electrocorticographhic Correlates of Language, NIH (R01, 5/01-4/06). 
  • Investigator (PI, Corey) Measuring the Hippocampus: A Comparison of Alternative Methods, MIRECC, (7/01-6/02)
  • Principal Investigator, AChE Inhibitor Therapy in the Treatment of Cognitive Deficits Associated with Static Brain Lesions.  Pfizer-Eisai (9/99-9/02).
  • Investigator (PI, van Zijl), Resource Center Grant for the F. M. Kirby Research Center for Functional Brain Imaging, NIH (8/01-7/06).
  • Investigator, Neurobehavioral Research Unit, Kennedy-Krieger Institute.  NICHD.  
  • Investigator, fMRI Correlates of Language Recovery in Children Undergoing Left Hemispherectomy.  Dana Foundation (7/00-6/03). 
  • Investigator, AchE Inhibitor Therapy in the Treatment of Memory Disorders in Patients with Epilepsy.  Pfizer-Eisai (3/01-3/03).
  • Investigator (PI, Hoehn-Saric), Assessment of Citralapam Treatment for GAD with fMRI, Forrest Laboratories. 
  • Principal Investigator, Verbal and Visual Semantic Object Processing Impairments.  K08 DC00099, 4/1/94- 5/31/00. 
  • Investigator, Investigation of Human Cortical Language Maps Using Complementary Functional Localization Techniques: Functional MRI, Cortical Electrical Stimulation, and Electrocorticographic Recordings.  Dana Clinical Hypotheses in Neuroscience Research Program, 1/97-1/00.
  • Investigator, Cognitive and Neuroanatomic Studies of Acquired Dyslexias.  NIH RO1  NS 29973, 12/1/92-11/30/98.
  • Investigator, Metrifonate Investigational Nationwide Trial (MINT).  Bayer Pharmaceutical Division, 12/97-12/98. 
  • Investigator, The Efficacy, Safety, and Tolerability of Lazabemide (Ro 19-6327) vs. Placebo, Administered for One Year in Patients with Probable Alzheimer's Disease (NINCDS/ADRDA Criteria) (PDL 1000P, dated 12/2/96).  Protodigm, 5/97-12/98.
  • Investigator, A 24-Week, Multicenter, Randomized, Double-Blind Placebo-Controlled Evaluation of the Efficacy and Safety of Donepezil Hydrochloride (E2020) in Patients With Dementia Associated With Cerebrovascular Disease  (E2020-307, 5/5/97).   Eisai, Inc., 9/97-12/98.
  • Investigator, An Open-label, Six Month Extension of SDZ ENA 713 Studies B351 and B352 to Prospectively Evaluate the Long-term Safety, Tolerability, and Efficacy of 1 through 6 mg b.i.d. (2-12 mg/day) SDZ ENA 713 in Outpatients with Probable Alzheimer's disease, Sandoz Pharmaceuticals Corporation, 1/96-12/97.   
  • Investigator, An Open Label, Multicenter Clinical Trial Evaluating the Safety and Efficacy of Donepezil Hydrochloride (E2020) in Patients With Alzheimer's Disease (Protocol #E2020-A001-314), Eisai America, 11/96-12/97.
  • Investigator, A 54-Week, Randomized, Double Blind, Placebo Controlled Evaluation of the Effects of Donepezil Hydrochloride (E2020) on Functional Outcome in Patients With Alzheimer's Disease With a Staged Crossover to Open Label Donepezil Hydrochloride (E2020) Treatment (Sponsor #E2020-A001-312), Eisai America, 9/96-12/97.
  • Investigator, A 52-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Study of  Milameline (CI979RU 35926) in Patients With Probable Alzheimer's Disease With Long-Term Open-Label Extension. Protocol 979-15-16, Warner-Lambert Company, 6/96-12/97.
  • Investigator, An Open-label, Multicenter, Extended Evaluation of the Safety and Efficacy of E2020 in  Patients with Alzheimer's Disease. Protocol E2020-A001-303, Eisai America, Inc., 7/94-5/97.
  • Investigator, Clinical Evaluation of the Safety and Efficacy of AF102B vs. Placebo in the Treatment of Patients with Dementia of the Alzheimer's Type, Protocol #94-001FL-105CR, Forrest Laboratories, 1/95-6/96.
  • Investigator, Open-label Extension of Study #94-001FL-1005CR to Evaluate Long-Term Administration of AF102B in the Treatment of Patients with Dementia of the Alzheimer Type, Forest Laboratories, Inc, 1/96-9/96.
  • Investigator, Promoting Recovery after Damage to the Human Brain: What Triggers the Recovery Process.  Seaver Foundation, 7/92-7/96.
  • Investigator, A Prospective, Double-blind, Placebo-controlled, Parallel Group Comparison of the Efficacy and Safety of Two Doses of SDZ 713, 1-4 mg per Day and SDZ ENA 713 6-12 mg per Day in  Patients with  Alzheimer's disease. Sandoz Pharmaceuticals Corporation, 4/95-5/96.
  • Investigator, Charles A. Dana Center for Study of Memory and Aging.  Dana Foundation, 7/92-7/95.
  • Investigator, A 30-week, Multicenter, Randomized, Double-blind, Placebo-controlled Evaluation of the Safety and Efficacy of E2020 in Patients with Alzheimer's Disease, Protocol E2020-001-302, Eisai America, 1/94-6/95.
  • Investigator, A Dose-ranging Study of F102B in Patients with Dementia of the Alzheimer's Type (DAT).  Forrest Laboratories.
  • Investigator, Language Organization Studied by Cortical Stimulation.  NINDS 1  R01 NS26553, 4/89-8/95.
  • Investigator, A Trial of 99MTechnetium Bicisate in Healthy Elderly Volunteers and Patients with Mild to Moderate Dementia of the Alzheimer Type,  Protocol 198-017, DuPont Merck Pharmaceutical Company, 2/93-6/94.
  • Investigator, The Neurobiology of Language (extension grant).  McDonnell Foundation-Pew Charitable Trusts, 1/93 - 9/93.
  • Investigator, The Neurobiology of Language.  McDonnell Foundation-Pew Charitable Trusts, 1/90-12/92.
  • Investigator, A Long Term Randomized Placebo Controlled Study of DuP 996 90 and 120 mg Daily in Patients with  Mild to Moderate Dementia of the Alzheimer Type (Long-term study) (U.S.A. Study); Protocol 996-025, DuPont Merck Pharmaceutical Company, 10/91-12/93.
  • Investigator, A Randomized Placebo Controlled Study of DuP 996 90 and 120 mg Daily in Patients with Mild to Moderate Dementia of the Alzheimer Type (U.S.A. Study), Protocol 996-019, DuPont Merck Pharmaceutical Company, 6/91-12/92.
  • Principal Investigator, Object Representation in Language and Sensory Cortices.  McDonnell Foundation-Pew  Charitable Trusts, 7/91-6/92.
  • Investigator, Oxiracetam in the Treatment of Patients with Cognitive Impairment Associated with Dementia of the Alzheimer's Type, SmithKline Beecham, 7/90-1/91.
  • Investigator, Safety and Efficacy of Long-term Use of Oxiracetam in the Treatment of Patients with Cognitive Impairment Associated with Dementia of the Alzheimer's Type, SmithKline Beecham, 10/90-1/91.
  • Investigator,  Dyslexia Studied by Direct Electrical Cortical Interference in Humans.  Seaver Foundation, 7/89-12/91.
  • Investigator, Controlled Pilot Trial of Dextromethorphan as Adjunct Therapy for Complex Partial Seizures, Nova Pharmaceuticals.

Personal Statement

Dr. Hart's research interests have focused on the neural basis of semantic memory in the human brain. His work spanning several decades has focused on identifying the organization of semantic memory in the human brain by proposing that there is both a categorical and featural structure to object memory that exists in multiple memory systems in the brain. His laboratory's recent studies have used functional neuroimaging and electrophysiological investigations to explore the neural mechanisms underlying combining these components of an object together to form an integrated object memory. They recently reported that one neural mechanism by which retrieval of this object memory can occur is via synchronizing gamma brain rhythms that are modulated by the thalamus. This mechanism of stored knowledge via the thalamus is modulated by the pre-SMA and caudate to facilitate effective retrieval. These findings have led to his group's proposal of the Neural Hybrid Model of Semantic Memory to account for how the brain stores and retrieves object memory. He is now investigating object memory and word finding deficits in multiple disease states in terms of both diagnosing and designing treatment options based on this model.


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