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Mathukumalli Vidyasagar
Cecil H&IDA Green Chr Sys Biology Bioengineering, Head, Bioengineering
Contact Address   800 W. Campbell Road, Richardson, TX 75080-3021     Office MailstopMail Box: EC39, Engineering & Computer Science South Building, Room No.: ECSS 3.908 
Email Address    Primary Phone Number 972-883-4679    Fax Number 972-883-4657    URL Web Link    Media Contact
Keywords Stochastic processes; computational biology; especially cancer biology.   
 Professional Preparation
 Ph.D.Electrical EngineeringUniversity of Wisconsin1969
 M.S.Electrical EngineeringUniversity of Wisconsin1967
 B.S.Electrical EngineeringUniversity of Wisconsin1965
Collapse Section Expand Section Research and Expertise
Current Research Interests
Web Link
My research interests are in the broad area of system and control theory, and its applications. At the moment I am working on problems in stochastic realization, specifically approximating high-order Markov and hidden Markov processes by lower-order processes, and the large deviation properties of such processes. On the applications front, I am interested in applying these (or any other appropriate) ideas to problems in computational biology and quantitative finance.
Collapse Section Expand Section Publications
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  YearPublication  Type
M. Eren Ahsen and M. Vidyasagar, "Mixing coefficients between discrete and real random variables: Computation and properties", to appear in IEEE Transactions on Automatic Control. Preprint at arXiv, 1208:1720.
Peer reviewed
M. Vidyasagar, ``A metric between probability distributions on sets of distinct cardinalities and applications to order reduction,'' IEEE Transactions on Automatic Control, 54(10), 2464-2477, October 2012. PDF
Peer reviewed
M. Eren Ahsen, Nitin K. Singh, Todd Boren, M. Vidyasagar and Michael A. White, "A new feature selection algorithm for two-class classification problems and their application to endometrial cancer", IEEE Conference on Decision and Control, Maui, Hawaii, December 2012, PDF
Conference paper
M. Vidyasagar and Yutaka Yamamoto, "Convergence and compactness of families of proper plants in the graph topology", IEEE Conference on Decision and Control, Maui, Hawaii, December 2012, PDF
Peer reviewed
M. Vidyasagar, Control System Synthesis: A Factorization Approach, Morgan & Claypool, 2011. (Completely re-typeset version, with several typos corrected, of Book No. 4 above) 
Collapse Section Expand Section Affiliations
Collaborators and Co-Editors
Seth Hutchinson (UIUC), R. L. Karandikar (Cranes Software Ltd.), Mustafa Khammash (UC Santa Barbara), Sharmila Mande (TCS), V. Raja Rao (TCS), Siva Kumar Reddy (TCS), J. H. van Schuppen (CWI, Netherlands), Somdatta Sinha (CCMB, Hyderabad), Eduardo Sontag (Rutgers), Mark Spong (UT Dallas), Claire Tomlin (UC Berkeley)
Graduate Advisors and Postdoctoral Sponsors
Prof. Thomas James Higgins, University of Wisconsin (deceased)
Thesis Advisor and Postgraduate-Scholar Sponsor During Past Five Years
Two Post-Doctoral scholars have been sponsored during the past Five years, namely: Vijay Sekhar
Chellaboina (U. Tennessee), Soura Dasgupta (U. Iowa).
Total number of graduate students advised: 14 Ph.D., 12 Masters, 26 in total.
Total number of Post-Doctoral scholars sponsored: 8.
Collapse Section Expand Section Appointments
DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
2009-PresentCecil & Ida Green Professor of Systems Biology ScienceBiongineering UT Dallas
2000-2009Executive Vice President  Tata Consultancy Services, Hyderabad, India
1989-2000Director  Centre for Artifi cial Intelligence & Robotics, Bangalore, India
1980-1989Professor  University of Waterloo, Waterloo, Canada
1977-1980Professor  Concordia University, Montreal, Canada
1973-1977Associate Professor  Concordia University, Montreal, Canada
1970-1973Assistant Professor  Concordia University, Montreal, Canada
1969-1970Assistant Professor  Marquette University, Milwaukee
 Synergistic Activities
Recent Synergistic Activities
  1. General Chairman, IEEE Multi-Systems Conference, Hyderabad, India, 2013.
  2. Member, National Organizing Committee, International Congress of Mathematicians, Hyderabad, India, August 2010.
  3. Joint organizer (along with Dr. Somdatta Sinha), Workshop on Applications of control theory and optimization in biochemical pathways, Hyderabad, India, August 2010.
  4. Member, Board of Governors, IEEE Control Systems Society, 2009.
  5. Chairman, National Subcommittee on Nanotechnology, Confederation of Indian Industry, 2009.
  6. Co-Guest Editor (along with Mustafa Khammash and Claire Tomlin), IEEE Transactions on Automatic Control/Circuits and Systems Special Issue on Systems Biology, January 2008.

 News Articles
Mathematical Model May Improve Cancer Drugs
UT Dallas News Center
A UT Dallas interdisciplinary researcher has launched a human genome analysis project intended to create a mathematical model that improves the efficacy of cancer drugs while reducing their manufacturing costs by as much as 30 percent.
A three-year, $305,000 grant from the National Science Foundation will fund Dr. Mathukumalli “Sagar” Vidyasagar’s development of a new method for detecting DNA sequence similarities.
“What I propose to do is to find mathematical models of how a cross section of cancer patients would react to a particular clinical trial drug,” he said.  “If it is likely that an unacceptably high fraction would react adversely, that would allow the developers to kill that program in a timely manner.”

Bioengineering Head to be Inducted as Fellow of Royal Society
UT Dallas News Center

Dr. Mathukumalli Vidyasagar, an internationally known expert in control and system theory, has been elected a Fellow of The Royal Society, the oldest continuously operating scientific society in the world.
Vidyasagar, head of theDepartment of Bioengineeringat The University of Texas at Dallas, joins the ranks of the most distinguished international scientists drawn from all areas of science, engineering and medicine.
Vidyasagar’s selection recognizes his contributions to various aspects of control and system theory, robotics, statistical learning theory and computational biology. His citation reads: “He has combined probability theory, combinatorics, and artificial intelligence to produce a beautiful unified theory of statistical learning, and used it to solve NP-hard design problems.”

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 Additional Information
Awards and Honors
  • 2013 John Ragazzini Education Award, American Automatic Control Council, "For outstanding contributions to automatic control education through publication of textbooks and research monographs"
  • 2012: Rufus Oldenburger Medal, American Society of Mechanical Engineering, "For his fundamental contributions to robust control theory, specifically L1-optimal control theory for linear control systems; nonlinear control theory, especially input-output stability theory; robotics, including the control of flexible beams; statistical learning theory and machine learning; and computational biology"
  • 2012: Fellow, The Institute of Physics, United Kingdom.
  • 2012: Fellow, The Royal Society, United Kingdom.
  • 2011: Harry H. Nyquist Lecture Award, American Society of Mechanical Engineers.
  • 2008: IEEE Control Systems Award, for "Promulgation of control science and engineering and contributions to robust control, robotics and statistical learning theory"
  • 2005: Jawaharlal Nehru Centenary Lecture Prize, Indian National Science Academy
  • 2004: Named as `One of Forty Tech Gurus' in the world by IEEE Spectrum
  • 2002: Best Paper Prize (Methodology) from the International Federation of Automatic Control (IFAC)
  • 2000: Hendrik W. Bode Lecture Prize, IEEE Control Systems Society
  • 1997: Fellow, Third World Academy of Sciences
  • 1997: Scientist of the Year, Defence Research and Development Organisation, Government of India
  • 1995: Distinguished Service Citation, College of Engineering, University of Wisconsin
  • 1994: Fellow, Indian National Academy of Science
  • 1992: Fellow, Indian Academy of Sciences
  • 1992: Fellow, Indian National Academy of Engineering
  • 1987: Best Paper Award, Society of Instrumentation and Control Engineers, Japan
  • 1984: Frederick Emmons Terman Award, American Society for Engineering Education
  • 1983: Fellow, IEEE
  • 1981: E. W. R. Steacie Memorial Prize, Natural Sciences and Engineering Research Council of
  • 1976: Prix Georges Montefiore, Association of Belgian Electrical Engineers Canada

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