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Warren J Goux
Associate Professor-Chemistry Department
Office MailstopMail Box: BE26, BE3510, Room No.: BE 3.510 
Email Address  Warren.Goux@utdallas.edu    Primary Phone Number 972-883-2660    URL UTD Webpage    Media Contact
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Heard, Linda L
 Professional Preparation
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 DegreeMajorInstitutionYear
 Ph.D.ChemistryUniversity of California, Santa Barbara1977
 B.A.PsychologyUniversity of Southern California1971
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Research Description
Neurofibrillary tangles (NFTs) are one of the two hallmark lesions of Alzheimer's disease (AD) and their accumulation has been used to assess the severity of the disease. They are composed of paired helical filaments (PHF), a form of amyloid resulting from the aggregation of the microtubule-associated protein tau. Our laboratory has found that peptides as short as 3-6 amino acids are able to initiate the formation of twisted filaments, similar to PHF. We believe that these short amyloid-forming peptides provide an excellent model for studying the structural basis of PHF and amyloid, in general. By understanding the structural basis for amyloid formation, a rational design of therapeutic agents able to prevent PHF accumulation can be undertaken. In addition to using short tau-related peptides to understand the basis of amyloid formation, they may be used as targeting agents for amyloid. For example, we have recently shown that contrast agents prepared from these peptides and a gadolinium chelate bind strongly to senile plaque and NFTs and may act as MRI probes for the diagnosis of AD.
Collapse Section Expand Section Publications
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  YearPublication  Type
2007
Bereszczak, J Rojas Quijano, F .A., Goux, W.J., Brancia, F .L. (2007) Relative Quantification of Tau-related Peptides using Guanidino-labeling Derivatization (GLaD) with Online-LC on a hybrid Ion Trap (IT) Time-of-F light (ToF) Mass Spectrometer Journal of The American Society for Mass Spectrometry 18(2):201-7.
Category: Journal of The American Society for Mass Spectrome...
Peer reviewed
2006
Warren J. Goux and Gabriela Luta (2006) Identification Of Carbonyl Compounds In The Urine Of Healthy Adults: An Evaluation Of Biomarkers Using Pattern Recognition Methods. Analytical Chemistry: An Indian Journal 2, 81-91.
Category: Analytical Chemistry: An Indian Joumal
Peer reviewed
2006
Federico A. Rojas Quijano, Dana Morrow, Barry M. Wise, Francesco L. Brancia, and Warren J. Goux (2006) Prediction of nucleation sequences from amyloidogenic propensities of tau-related peptides. Biochemistry 45(I4):463 8-52.
Category: Biochemistry
Peer reviewed
2006
Hideyo Inouye, Deepak Sharma, Warren J. Goux, Daniel A. Kirschner. (2006) Structure of Core Domain of Fibril-Forming PHF/Tau Fragments. Biophysical Journal. 90(5), 1774-89.
Category: Biophysical Journal
Peer reviewed
2005
Jimmy Tai-Nin Chow, David A.Williamson, Kenneth M.Yates and Warren J .Goux (2005) Chemical characterization of the immunomodulating polysaccharide of Aloe vera L. Carbohydrate Research 340, 1 131-1142.
Category: Carbohydrate Research
Peer reviewed
Collapse Section Expand Section Affiliations
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Nanotech Institute
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DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
1986-PresentAssociate Professor of Chemistry  The University of Texas at Dallas
1981-1986Assistant Professor of Chemistry  The University of Texas at Dallas
1979-1981Assistant Research Chemist-Lecturer  University of California, San Francisco, California
1977-1979Postdoctorate Research Associate  Indiana University, Bloomington, Indiana
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 Additional Information
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47 publications in related fields

Memberships
American Chemical Society, Society for Neuroscience

Patents
  • "Enzymatic Synthesis of Isotopically Labeled Carbohydrates from Labeled Pyruvate", U.S. Patent # 4,656,133, 1987.
  • "Enzymatic Synthesis of Isotopically Labeled Carbohydrates, Nucleotides and Citric Acid Cycle Intermediates", US Patent #5,227,296, July, 1993.
  • "Enzymatic Synthesis of Isotopically Labeled Carbohydrates", US Patent # 5,302,520, April, 1994

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