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    Faculty Profile — Is this you? Login to edit.Last Modified Time: 12:17:59 PM Wed, 24 Oct 2012 
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Mehmet Candas
Senior Lecturer I-Biology Department
Office MailstopMail Box: FO31 
Email Address  candas@utdallas.edu    Primary Phone Number 972-883-6338    Media Contact
 Professional Preparation
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 DegreeMajorInstitutionYear
 Ph.D.Molecular Biology and GeneticsSouthern Methodist University Dallas, Texas1995
 M.S.BiochemistryMiddle East Technical University, Ankara, Turkey1988
 B.S.Biology and BiochemistryMiddle East Technical University, Ankara, Turkey1985
Collapse Section Expand Section Research and Expertise
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Research Background and Interests

After earning my bacheIor's and master's degrees with specialties in biochemistry and cancer biology, I completed my doctoral dissertation with studies in the aging process, focusing on the glutathione metabolism and oxidative stress. In 1995, l joined a biotechnology company and worked on development of recombinant protein expression vectors and live-bacteria vaccine delivery technologies for immune stimulation and treatment of infectious diseases and cancer. In 1997, I became associated with The University of Texas at Dallas where I started as a research scientist and studied bacterial metabolism and virulence regulation. Later, in 1999-2006, I served as the Research Manager for Center for Applied Biology (Center for Biotechnology and Bioinformatics). During this time, I focused my studies on bacterial and insect systems as paradigms for microbe-host interactions and investigated structural and functional aspects of cadherins and cell death signaling cascades. The studies provided new insight into the biological mechanisms of Bt toxin action and how changes in gene expression and protein accumulation profiles consolidate with physiological responses associated with insect resistance to biopesticides. At the Center, I also developed new research proposals and helped establish a spin-off company emphasizing agricultural and environmental biotechnology. As a scientific co-founder and internal scientific consultant to the company, I implemented integrated approaches involving genomics, proteomics and bioinformatics applications. The applications facilitated construction and screening of versatile gene libraries and enabled generation of protein expression systems and ceII-based assay platforms.

My current interests focus on overlapping themes that underline the principles of cell adhesion and cell communication and how cells integrate these signals into survival or death pathways.  My goal is to bring new insights into these biological functions, understand their evolutionary significance, and construct phenotypic and process models that can be exploited in biotechnology and medicine.  I have been studying biological mechanisms that establish the biochemical and genetic basis of cellular responses to their environment, including those involved in cell-cell and cell-material interactions, oxidative stress, microbial toxins, drug and insecticide action.  What motivates me to work in this field is the continuing challenge to understand biological systems and their emergent properties through better use of scientific data with computers and interdisciplinary technology applications.   Main approaches that I employ in my studies include bioinformatics, in silico methods (databases, conceptual clustering, ontology and semantic analysis, comparative/homology modeling, virtual scrteening), functional genomics and proteomics applications along with traditional biochemistry, molecular biology, microbiology and cell biology techniques.

Collapse Section Expand Section Publications
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 1  2 3 4  
  YearPublication  Type
2007
Univalent Binding of the Cry1Ab Toxin of Bacillus thuringiensis to a Conserved Structural Motif in the Cadherin Receptor BT-R1. Biochemistry, 46 (35), 10001 -10007 (2007).
Category: Biochemistry (ACS Publications)
Peer reviewed
2006
A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensis. Proc. Natl. Acad. Sci., U S A. 103:9897-902 (2006).
Category: Proceedings of the National Academy of Sciences, U...
Peer reviewed
2005
Cytotoxicity of Bacillus thuringiensis Cry1Ab Toxln Depends on Specific Binding of Toxin to the Cadherin Receptor BT-R1 Expressed in Insect Cells. Cell Death Differ. 12, 1407-1416 (2005).
Category: Cell Death & Differentiation
Peer reviewed
2004
Selective antagonism to the cadherin BT-R1 interferes with calcium-induced adhesion of epithelial membrane vesicles. Biochemistry 43:1393-1400 (2004).
Category: Biochemistry (ACS Publications)
Peer reviewed
2003
Insect resistance to Bacillus thuringiensis: Alterations in the Indianmeal moth larval gut proteome. Mol. Cell Proteomics 2:19-28 (2003).
Category: Molecular & Cellular Proteomics
Peer reviewed
Collapse Section Expand Section Presentations and Projects
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  1  2 3 4 5 6 
Start DateEnd DatePresentation/Project
2012 2013 Characterization of enzyme active sites and potential ligand interactions through comparative modeling of protein three-dimensional structures.

UT Dallas Undergraduate Research, Richardson, TX

2012 2013 Homology modeling and virtual screening of protein structure for potential ligand interactions.

UT Dallas Undergraduate Research, Richardson, TX

2011 2012 Bioinformatics framework for conceptual mapping of relationships between folic acid and neural tube defects.

UT Dallas Undergraduate Research Scholar Award Program, Richardson, TX

2010 2010 Structuring multidisciplinary biology courses - A case study: Cellular Microbiology.

Experimental Biology Meeting, Anaheim CA

2010 2010 Post-genomics era topics in multidisciplinary biology courses.

Experimental Biology Meeting, Anaheim CA

Collapse Section Expand Section Affiliations
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Current
Medical Technology Program Board, UT Southwestem Medical School (Dallas, TX)
Board for Knowledge, Southern Methodist University (Dallas, TX)
Past
Association of Clinical Research Professionals (Alexandria, VA)
American Association for Advancement of Science (Washington, DC)
American Chemical Society (Washington, DC)
Society of Industrial Microbiology (Fairfax, VA)
New York Academy of Sciences (New York, NY)
American Society for Microbiology (Washington, DC)
American Society for Tropical Medicine (Northbrook, IL)
Collapse Section Expand Section Appointments
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DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
10/1999-08/2006Research Engineering ScientistCenter for Applied Biology The University of Texas at Dallas
10/1999-08/2006Chief technology Officer  Biological Targets, Inc., Dallas, Texas
10/1997-10/1999Postdoctoral Research AssociateDept of Molecular & Cell Biology The University of Texas at Dallas
09/1995-09/1997Scientist  Cytoclonal Pharmaceutics, Inc., Dallas, TX
09/1989-09/1995Research and Teaching AssistantDepartment of Biological Sciences Southern Methodist University
09/1987-04/1989Research AssistantDepartment of Biology Middle East Technical University, Ankara, Turkey
09/1986-08/1987Research and Teaching AssociateDepartment of Medical Biology and Clinical Genetics The University of Ankara Medical School, Ankara, Turkey
09/1984-07/1986Technical AssociateClinical Biochemistry and Radiobiology Unit Technical Associate Duzen Laboratories, Inc., Ankara, Turkey
08/2006-PresentSenior LecturerDept of Molecular & Cell Biology The University of Texas at Dallas
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 Additional Information
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Teaching Activities

Biotechnology Laboratory (BIOL 6384) –  applications of biotechnology methods in a laboratory setting; isolation and analysis of DNA, proteomics (theories and concepts related to research and clinical studies, 1D and 2D SDS PAGE, liquid chromatography, instrumentation basics of mass spectrometry, ionization techniques, peptide fragmentation, peptide fingerprinting, and protein identification and bioinformatics applications for protein sequence analysis and BLAST Searching), real time PCR, ELISA, FACS cell sorting, transfection of animal cells, immunocytochemistry and confocal microscopy.

Introduction to Biotechnology (BIOL 5V00)–  overview of techniques utilized in biomedical research and bioprocessing/biomanufacturing applications in the pharmaceutical, agricultural and environmental biotechnology industries;  principles of common methods involving protein chemistry, molecular and cell biology; macromolecular separation, purification and analysis of biological molecules, chromatography, electrophoresis, molecular and cellular labeling, detection and assay methods, use of antibodies, DNA sequencing, recombinant DNA, protein engineering, nucleic acid primers, amplification and hybridization-based methods, PCR, RT-PCR, qPCR, gene libraries, genotyping, gene expression analysis, microarrays, bioinformatics, genomics, proteomics, DIGE, ICAT, mass spectroscopy, and systems biology-based approaches; molecular diagnostics, biomarkers and clinical trials

Cellular Microbiology (BIOL 4V00)– examination of microbe-host cell interactions from cell biology perspective; bacterial virulence and pathogenesis, toxins, intracellular parasitism and subversion of host cell functions, cellular responses, innate and acquired immunity, inflammation, antimicrobial therapy, vaccines, microbial genomics, microarrays and proteomics applications in medical microbiology

Research and Advanced Writing (BIOL 4390) ­–  planning and conducting thematic research; strategies for analyzing scientific literature, examining original research articles, communicating facts and theories by coherent writing

Cell and Molecular Biology Laboratory (BIOL 4380)– DNA manipulation, cloning, bacterial transformation, plasmid mapping, PCR, DNA fingerprinting, mutagenesis and AMES test, centrifugation, cell fractionation, enzyme assays, mammalian cell culture techniques, transfection and ion-trapping

Biochemistry I (BIOL 3361) –  Structures and chemical properties of amino acids; protein purification and characterization; protein structure and thermodynamics of polypeptide chain folding; catalytic mechanisms, kinetics and regulation of enzymes; energetic  of biochemical reactions; metabolism; roles of coenzymes and prosthetic groups in redox reactions; pathways for carbohydrate oxidation; glycogen metabolism; glucose synthesis; electron transport and oxidative phosphorylation.

Biochemistry II (BIOL 3362) –  Structure and function of lipids, biological membranes, membrane proteins, transport mechanisms across cell membrane, fatty acids, lipid metabolism, biosynthesis of cholesterol, prostaglandins and hormone action, metabolic integration, and metabolic disorders

Eukaryotic Molecular Cell Biology (BIOL 3102) –  Structural organization of eukaryotic cells; regulation of cellular activities; membranes and transport across cell membrane; cell specialization; cell signaling molecules and cell surface receptors; signal transduction pathways that control gene activity; the organization and control of the eukaryotic cytoskeleton; mechanisms of protein targeting to cellular organelles; vesicle traffic, secretion and endocytosis; the molecular regulation of the eukaryotic cell cycle, and aspects of the molecular basis of cancer.

Introduction to Modern Biology I (BIOL 2311) –  Introductionto basic concepts with an emphasis on the molecular and cellular organizations and mechanisms associated with biological phenomena. Topics include the chemistry and metabolism of biological molecules, classical and molecular genetics, selected aspects of developmental biology, as well as study of major groups of biological organisms such as bacteria, viruses and fungi.

Introduction to Modern Biology II (BIOL 2312) –  Fundamental aspects of mammalian physiology with an emphasis on the human body systems, organ development, regulation of organ functions and physiological mechanisms regulating the internal environment (homeostasis).

Body Systems (BIOL 1300) –  Introductory to human physiology in relation to molecular, cellular and anatomical structures; examination of human body and organ systems with model-based lab exercises; physiological functions associated with homeostasis and integration of metabolism, basic information about diseases and disorders with special considerations to preventative and self-care approaches.

Natural Science & Mathematics Freshman Seminar  (NATS1101) –   An overview of approaches to basic study and learning strategies, critical thinking, problem solving, group work and other skills as well as studentship and professional ethics; inter-disciplinary and cross-disciplinary connections within the programs of the School of Natural Science and Mathematics as well as their relationship to other scientific, technology and engineering fields and interdisciplinary applications.  Emphasis is given to discussions on current and emerging themes of scientific research, education and technology applications in the 21st century.

 

Courses under development

Biology of Aging – tentative topic: the evolution and genetics of aging; theories on aging, nutritional and physiological aspects of aging and longevity; mammalian metabolism in aging; aging and cancer, pathophysiology of aging and age-related diseases

Tissue Engineering - tentative topics: current concepts, research strategies and clinical applications involving ex vivo cell cultivation and tissue culture, cell-based organ support systems, cell and tissue transplantation, regenerative medicine, cell-based therapies, drug screening and toxicology assays with tissue surrogates; molecular and cellular aspects of mammalian cells and tissues; cell adhesion, intracellular signaling, differentiation, proliferation, stem cells, cell culture, cell manipulation, biomaterials, biocompatible and biomimetic interfaces, scaffolds and bioreactors.


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