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John G Burr
Associate Professor-Natural Sciences & Mathematics, School of, Associate Dept. Head -Natural Sciences & Mathematics, School of
Office MailstopRoom No.: FN 3.110 
Email Address  John.Burr@utdallas.edu    Primary Phone Number 972-883-2508    URL John Burr's Web Page    Media Contact
 Professional Preparation
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 DegreeMajorInstitutionYear
 Ph.D.Molecular BiologyUniversity of California, Berkeley1973
 B.S.ChemistryUniversity of California, Riverside1967
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Research Interests

Oncogenic Transformation by Rous Sarcoma Virus

Rous sarcoma virus (RSV) causes cancer in chickens and other avian species. It also efficiently infects avian cells in culture and rapidly converts (transforms) them into tumor cells. The viral gene responsible for the oncogenicity (cancer-causing ability) of this virus is called the src gene, and it encodes a protein termed pp60v-src. Pp60v-src is a tyrosine kinase (i.e., it phosphorylates its substrate proteins on tyrosine residues). In RSV-transformed fibroblasts, pp60v-src is associated with both cellular membranes and the submembraneous cytoskeletal matrix (1). Substrates for the tyrosine kinase activity of pp60v-src are to be found in both of these sub-cellular locations.

A useful way to identify substrates for tyrosine kinases like pp60v-src has been to prepare antibodies that recognize the hapten phosphotyrosine and use these antibodies as probes for phosphotyrosine-containing proteins. We have used this approach to examine the tyrosine phosphoproteins in RSV-transformed chicken embryo fibroblasts (RSV-CEF) (2,3). In immunoblots with these antibodies, we identified a large number of proteins phosphorylated on tyrosine in a transformation-specific manner.

Among these proteins is a 120-kDa membrane-associated protein ("p120"), and 63-kDa tyrosine phosphoprotein that is associated with the cytoskeleton ("p63/SAM68"). The phosphorylation of both of these proteins is greatly reduced in cells infected with src gene mutants of RSV that are defective in their ability to transform cells. Our research is centered on investigating the role these two proteins play in growth regulation. In the process of characterizing these two proteins, we have cloned the cDNAs for two other interesting proteins, "p120psh" and "SAM68-related protein" (SRP)

Collapse Section Expand Section Publications
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 1  2 3  
  YearPublication  Type
2006
J .G. Burr 2006 Chapter 1: Tools of the Cell Bio1ogist, in Medical Cell Biology, 3rd Ed., S.Goodman, Ed. Lippincott, Williams & Wilkins (in press).
Book chapters
1999
Lee, J. and J.G. Burr 1999 Salpα and Salpβ, growth-arresting homologs of Sam68. Gene 240, 133-147.
Category: Gene
Peer reviewed
1998
Suh, K.S., Ting, Y.T., and J.G. Burr 1998 An avian cDNA encoding a tyrosine-phosphorylated protein with PDZ, coiled-coil and SAM domains. Gene 219, 111-123.
Category: Gene
Peer reviewed
1989
Van Wart-Hood, J.E., M.E. Linder and J.G. Burr 1989 TPCK and quercetin act synergistically with vanadate to increase protein-tyrosine phosphorylation in avian cells. Oncogene 4, 1267-1271.
Category: Oncogene
Peer reviewed
1988
Linder, M.E. and J.G. Burr 1988 Nonmyristoylated pp60v-src fails to phosphorylate proteins of 115-120kDa in chicken embryo fibroblasts. Proc. Natl. Acad. Sci. USA 85, 2608-2612.
Category: Proceedings of the National Academy of Sciences, U...
Peer reviewed
Collapse Section Expand Section Affiliations
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Students supervised
M.S. Awarded
1985 Joseph T. Murphy (August)
1988 Katrina Latham (December)
1988 Daniel M. Shusterman (December)
1990 Yuan-Tsang Ting (Interim, December)
1991 Nguyen, Hao (Interim, December)
1992 Sang Dae Lee (August)
1993 Yuko Hata (December)
1994 Kwang Suh (Interim, May)
1994 Sharmilla Pandhaxipande (Interim, May)
1994 Walid Moghrabi (August)
Ph.D. Awarded
1987 Jacqueline C. Lui (May)
1987 Maurine E. Linder (December)
1989 Jill E. Van Wart-Hood (December)
1991 Teri G. Boulton (December) [Co-chair with Dr. M. Cobb, UTSW]
1993 Yuan-Tsang Ting (December)
1995 Hao Nguyen (May)
1998 Kwang S. Suh (August)
1999 Ju-Seog Lee (May)
Collapse Section Expand Section Appointments
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DurationRankDepartment / SchoolCollege / OfficeUniversity / Company
1989-1989Associate Professor of Biology  The University of Texas at Dallas
1986-1986Visiting ScientistDepartment of Biomedical Science and Human Oncology University of Turin, Turin, Italy
1983-1983Assistant ProfessorDivision of Life Sciences The University of Texas at San Antonio
1983-1988Assistant Professor of Biology  The University of Texas at Dallas
1980-1982Research ScientistDepartment of Biology Massachusetts Institute of Technology
1976-1980Research AssociateDepartment of Biology Massachusetts Institute of Technology
1975-1976Sponsored Research FellowCenter for Cancer Research Massachusetts Institute of Technology
1973-1975Research FellowDepartment of Physiology Harvard Medical School
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 Additional Information
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Awards and Fellowships
  • 1967-72 NIH Predoctoral Trainee
  • 1974 Developmental Biology Postdoctoral Fellowship, Harvard University
  • 1980-83 Co-principal Investigator (with Dr. J .M. Buchanan) on three-year NIH research grant, "Cytological and Biochemical Studies on Viral-Specific Proteins". $225,937.
  • 1988-91 Three year NSF travel grant: "U.S.-Italy Cooperative Research: Purification of Tyrosine Phosphoproteins." Grant #INT-8715273, $12,450.
  • 1988-91 Three year NSF research grant: Purification of Tyrosine Phosphoproteins." Proposal #DCB-8812232, $306,716 total costs. Awarded, but declined in favor of the NIH grant listed below.
  • 1988-94 Five year NIH research grant: "Purification of Tyrosine Phosphoproteins." Grant #1 R29 CA47098-O1A1, $498,484 total costs. (with a no cost extension to 11/30/94)
  • 2000 Appointed to Board of Advisors, Cytoclonal Pharmaceutics, Inc.
  • 2001 Natural Sciences and Mathematics Outstanding Teacher Award
  • 2002 Appointed Adjunct Professor of Mathematics/ Science Education

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